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Coronavirus’ Spike Protein

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The Novel Coronavirus’ Spike Protein Plays Additional Key Role in Illness

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease

By Yuyang Lei.

Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. A major new study shows that the virus spike proteins (which behave very differently from those safely encoded by vaccines) also play a key role in the disease itself.

The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications and could open the door for new research into more effective therapies.

“A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”

Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy.

While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.

In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to an animal model’s lungs and arteries, proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.

The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.

Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on their own.

“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”

The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.

Artificial Spike Proteins And The End Of Human Health

It is hard to believe, and it is certainly new, that a virus can actually cause long-term changes to an infected person’s genes. It’s incredibly scary that results from a new cell study found that the SARS-CoV-2 spike protein can bring about long-term gene expression changes even when exposure is minimal.

Moderna’s mRNA-1273 consists of a strand of mRNA that tells the body to produce the spike protein the coronavirus uses to latch onto human cells. The strand is like one side of a zipper; the “teeth” are a sequence of chemical letters that cells read to produce the 1,273 amino acids that make up the spike protein. If the vaccine works as intended, the body will start producing the proteins soon after injection. What could go wrong?

Plenty is going wrong. Yet the mainstream press, Youtube, Facebook, Twitter, the CDC, FDA, WHO, the vaccine companies, and everyone who is mandating COVID vaccines are ignoring the thousands of people dropping dead soon after their shots and the hundreds of thousands of injured, tens of thousands seriously, all of which are being counted in Europe and the United States by official vaccine reporting systems. How can we be so betrayed? How can anyone with a human heart deny the death and deep suffering of others?

The research about the spike proteins, not the virus itself, is starting to explain why some COVID-19 patients — referred to as COVID long-haulers — experience symptoms such as shortness of breath and dizziness long after clearing the infection.

The findings sustain the suspicion that this was no fluke of nature but a product of genetic engineering of the worst kind. Spike proteins produced by the body might also explain why so many women, not reported into the vaccine reporting systems, have dramatic changes in menstruation, according to the British Medical Journal. Furthermore, spike proteins might explain why even unvaccinated women exposed to vaccinated women are having similar problems.

These vaccines were deliberately designed to function as self-replicating vaccines. Self-spreading or self-replicating vaccines could indeed entail serious risks, and the prospect of using them raises challenging questions. Self-spreading vaccines are essentially genetically engineered viruses designed to move through populations in the same way as infectious diseases, but rather than causing disease, they are supposed to confer protection. But that does not seem what the COVID vaccines are doing. VAERS Reporting System: At Least 9,245 Americans Tested Positive for COVID-19 After Vaccination; 132 Dead.

SARS-CoV-2, the virus that causes COVID-19, is covered in tiny spike proteins. During infection, the spike proteins bind with receptors on cells in our body, starting a process that allows the virus to release its genetic material into the inside of the healthy cell. The spike protein is an arm-like apparatus that the virus uses to attach to and enter healthy cells. At the tip of the spike protein rests a string of three amino acids called RGD. This structure is known for connecting cells to each other in the body.

Dr. Lee Makowski from Northeastern University published his hypothesis in the journal Viruses, believes the spike protein found on the surface of the virus might mimic proteins that regulate blood vessels and control the formation of blood clots, which could explain many of the non-respiratory complications of COVID-19.

Early autopsy reports revealed COVID-19 patients were suffering from huge amounts of thick, coagulated blood and dysfunctional blood vessels. It seems like the spike proteins’ tips were tearing through body tissue instead of repairing them—causing highly uncommon side effects of respiratory diseases. Perhaps it is not the virus itself that is wreaking biological havoc but the spike protein itself.

If true, we are in big trouble because spike proteins are exactly what the COVID vaccines are instructing the body to manufacture in great numbers. For SARS-CoV-2, the vaccines produced by Pfizer/BioNTech and Moderna give instructions to our cells to make our own version of the spike protein, which happens shortly following immunization.

The postmortem evidence plus his own experience with something called “COVID toes”—an odd side effect of the disease that causes heightened blood vessel formation in the toes, turning them bright red—led Makowski to speculate that something about the virus might be causing abnormal blood-related complications.

The researchers found that cultured human airway cells exposed to low and high purified spike protein concentrations showed differences in gene expression that remained even after the cells recovered from the exposure. The top genes included ones related to inflammatory response. Thus it is not surprising that a fine physician like Dr. Lee Merritt is starting to believe that the spike proteins made from vaccinated people’s cells are transmittable.

Nicholas Evans, a master’s student at the Texas Tech University Health Sciences Center, said, “Symptoms seen in patients may initially result from the spike protein interacting with the cells directly.” The inference is that the spikes make long-term changes to human lung cells, which speaks of a medical disaster doctors have not confronted before.

All COVID vaccines —the mRNA, DNA, viral vectored, recombinant protein, viral-like particles, and peptide-based vaccines—use the coronavirus’s spike protein. The CDC had stated that the spike protein of SARS-CoV-2 is harmless, which assures that current Covid-19 vaccines would be safe. Could they be wrong?

The CDC says, “COVID-19 mRNA vaccines give instructions for our cells to make a harmless piece of what is called the “spike protein.” The spike protein is found on the surface of the virus that causes COVID-19.” A case is just beginning to be made that this harmless piece of protein is deadly. Since these are all experimental genetic injections with no long-term studies, we will eventually find out what it means in terms of human health when we play around with mRNA. Don’t be surprised if the news is devastating.

The spike protein the vaccines create is the same one found on the virus’s surface that causes COVID-19. “The spike protein itself cannot cause an infection of COVID,” or at least that is the prevailing thinking, but the question to be answered is, can the spike protein itself cause human misery and death?

The COVID vaccines (from Oxford/AstraZeneca, Pfizer/BioNTech, and Moderna) all work by getting our cells to make copies of the virus spike protein. The Oxford vaccine achieves this by introducing the spike protein gene via an adenovirus vector. The other two vaccines deliver the spike protein gene directly as mRNA wrapped in a nanoparticle.

When our cells make the spike protein, they would like us to believe that our immune response will recognize it as foreign and start making antibodies and T cells that specifically target it. (We have to be more aware that none of these shots are like traditional vaccines, meaning they are not vaccines but genetic delivery devices.)

Back in December 2020, Dr. J. Patrick Whelan of UCLA sent a warning to the FDA. “It appears that the viral spike protein that is the target of the major SARS-CoV-2 vaccines is also one of the key agents causing the damage to distant organs that may include the brain, heart, lung, and kidney.”

“I am concerned about the possibility that the new vaccines aimed at creating immunity against the SARS-CoV-2 spike protein (including the mRNA vaccines of Moderna and Pfizer) have the potential to cause microvascular injury to the brain, heart, liver, and kidneys in a way that is not currently being assessed in safety trials of these potential drugs.”

Whelan explained that people who recover from COVID-19 even with mild symptoms might have ongoing myocardial (heart) inflammation problems. This is not related to the virus or even the illness, but to the spike protein on the virus, which can bind to ACE-2 receptors in the heart, as well as in the brain and other organs such as the liver and kidney, and continue to cause health problems via injury to the smallest vessels.

Dr. Richard Vander Heide, a professor in the Department of Pathology at Louisiana State University who performed autopsies of COVID patients, when examining the lungs of a man who died of the disease at the age of 44, found that hundreds, if not thousands, of blood clots had formed in the patient’s lungs.

“Inflammation in the mice with lipopolysaccharide (LPS; a bacterial toxin) treatment further enhanced the brain uptake of spike proteins. This is because the inflammation had disrupted the blood-brain barrier integrity, making it more permeable to foreign invaders.” This would explain why overweight people are more likely to suffer from serious coronavirus infections, with the associated risk especially prevalent among those younger than 40, according to a new study. The more overweight a person is, the more we find chronic inflammation in the body.

Dentists are complaining that their otherwise healthy patients are suffering from gum disease, which causes systemic inflammation in the body.

Meinhardt et al. (Nature Neuroscience 2020, in press) show that the spike protein in brain endothelial cells is associated with microthrombi formation (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating the virus.

Whelan point-blank tells the FDA that the spike protein of Covid-19 used in the vaccine is causing severe problems. Thus, by injecting this SPIKE protein via the vaccine, we may be creating a whole range of ongoing problems in the population — problems not being considered in the safety studies of any of the vaccines.

We should all take notice that Pfizer knows no humane limit. Experiments with children now have us having to witness the first vaccine death of a two-year-old reported into the VAERS vaccine reporting system. The child received her second (Dose 2) experimental Pfizer mRNA shot on February 25. She apparently developed some sort of serious adverse reaction on March 1. The baby was dead on March 3.

As the pandemic and vaccine disaster bites civilization deeper, one has to read the excuses for the terrifying world of genetic engineering. We get lessons everywhere on how genetic vaccines work. They harness human cells to become miniature vaccine factories in their own right. Instead of virus proteins, the vaccines contain genetic instructions that prompt the body to produce them. Those instructions are carried via messenger RNA, or mRNA.

The feasibility of inhaled RNA for passive transfection has been proven in several studies. Messenger RNA (mRNA) as a means for passive immunization has been extensively studied for years. Inhaled RNA may lead to the passive synthesis of non-infectious spike proteins using cell transfection machinery.

What does this mean? Does it mean that the COVID spike protein made by the human body after being vaccinated can escape through breathing and infect non-vaccinated people? It is a horrible thought that the madmen who created the virus through gain of function experimentation are in league with similar madmen in the pharmaceutical business who will use their vaccine to spread the spike proteins deeper into human populations?

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6 COMMENTS

  1. This is bill gates wet dream, depopulation via vaccines. He stated it many times and him and his elite mates got handed the perfect opportunity to mass sterilize a majority of the world.

    I bet ole bill and his scientists havent got the jab, theyre clued up and prob wear full bio suits when near it.

    The worrying thing emerging is the shedding to the unvaccinated.

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  2. My suspicious mind is thinking why would you need a third vaccine, unless it’s full of something to try and stop the spike protens from working.
    A vaccine you take to stop the first two working?

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  3. I think on currently available information as Ed has provided that ardern may have inadvertently protected NZ whilst the effects of the disease and the “vaccination” programmes results are revealed. Who would have thought that abject incompetence and lies would confer such benefits, but proves the adage that even a stopped clock is accurate twice a day. Another potential benefit is the preference to be given to a certain section of population who already are more prone to the disease, could ardern be a covert supporter of gates & soros?

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  4. Article states “the virus spike proteins… behave very differently from those safely encoded by vaccines”

    How do we know the so-called safely-encoded spike proteins will continue to dutifully behave differently over the lifetime of the person who’s been vaccinated and all of whose cells have now been modified by the Medsafe-not-quite-yet-approved and increasingly-Government-mandated vaccine to manufacture those spike proteins?

    FFS.

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