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Scientists Discover Aggressive Coronavirus Mutation That Will Probably Render Vaccines Useless

A coronavirus strain isolated in India carried a mutation that could threaten the race to develop a vaccine.

The prospect that SARS-CoV-2, the “novel” coronavirus responsible for causing the illness COVID-19, might be mutating and evolving as it spreads across the globe has been such a terrifying prospect for the scientific community, that medical experts like Dr. Anthony Fauci seem to avoid even engaging on the topic.

Asked about the possibility of viral mutation during one of the White House’s inaugural task force press briefings, Dr. Fauci assured the public that scientists have found “no evidence” of any concerning mutations, though the prospect that a mutated version of the virus might return during next year’s flu season has kept some virologists up at night with nightmares about needing to start the vaccine clock from zero.

The problem is that vaccines often aren’t as effective against viruses that mutate, like the flu does every season (that’s why you need to keep getting that flu shot year after year).  And now, a new scientific paper that – like most of the coronavirus research being cited in the press – has yet to be peer reviewed claims to have identified a mutation in a sample of the virus collected in India that could create serious problems for researchers working on a vaccine.

Monitoring the mutation dynamics of SARS-CoV-2 is critical for the development of effective approaches to contain the 21 pathogen. By analyzing 106 SARS-CoV-2 and 39 SARS genome sequences, we provided direct genetic evidence that 22 SARS-CoV-2 has a much lower mutation rate than SARS. Minimum Evolution phylogeny analysis revealed the putative original status of SARS-CoV-2 and the early-stage spread history. The discrepant phylogenies for the spike protein and it receptor binding domain proved a previously reported structural rearrangement prior to the emergence of SARS-CoV-2. Despite that, we found the spike glycoprotein of SARS-CoV-2 is particularly more conserved, we identified a mutation that leads to weaker receptor binding capability, which concerns a SARS-CoV-2 sample collected on 27th January 2020 from India. This represents the first report of a significant SARS-CoV-2 mutant, and raises the alarm that the ongoing vaccine development may become futile in future epidemic if more mutations were identified.”

The ominous discovery underscores how the virus’s destructive potential will likely be tied to the vagaries of viral evolution.

Fortunately, the team appeared to confirm an earlier finding by a team of researchers in Italy that the virus “has a much lower mutation rate and genetic diversity” than SARS, which means that a vaccine will likely be able to treat wide swaths of people before becoming ineffective as the virus changes and evolves.

However, this new finding shows that it’s not just the speed of the mutation that matters, but the specific nature of the mutations, when scientists are developing a vaccine.

Experts say that a vaccine could take up to two years to develop, and some city officials have warned that life likely won’t return completely back to normal until a vaccine is ready for mass production. But a mutation could throw a wrench in this process, transforming the process of developing a workable vaccine into a “cat and mouse” game – or at the very least lengthen the time it takes for the initial vaccine to be developed.

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7 COMMENTS

  1. “Dr. Fauci assured the public that scientists have found “no evidence” of any concerning mutations,”

    Hahahahaha, Oh my aching sides, is that like the Chinese scientists who found “no evidence” of human to human transmission?

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  2. There was no way to create a ‘safe environment’ unless it was proven everyone who was in contact with others was healthy, but social distancing was the best thing we could do to minimise the risk of infection, he says.

    As for those particles left behind from a sneeze to linger in the air? They stay there for hours, Chris says.

    “Those particles will drift around in the air for hours, so if someone was in an area where they were being symptomatic for a protracted length of time, they’re slowly going to increase the amount of infectious material in the air, aren’t they.

    “And so there reaches a point where they have significantly boosted the infectivity of a patch of air when people go through it.

    “So I don’t think it’s as simple as saying it’s 2 metres because viruses don’t come with tape measures.”

    https://www.sunlive.co.nz/news/240164-virologist-on-latest-covid19-science.html

    The article is worth a read.

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    • 2m distancing is bollocks in anything but motionless air. When passing others I’m conscious of whether I’m upwind or downwind.
      A 10 kmph breeze is 3 m/s. So if downwind, your 2m safe zone is reduced to 0m in .6 of a second.

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      • Exactly. I was out walking the other day and passed a woman coming the other way. We each moved aside on the narrow track so our closest point of passing was about 2 metres as I carried on down the track her perfume was detectable in the air for at least thirty metres.

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  3. That’s why opening schools is crazy until we have a much better idea of what is going on. Keep the schools closed but open up business.

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    • Can’t do that, it’s not the socialist way !~
      People are now starting to get fucked off and desperate to get their businesses up and running again !~

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    • The school opening strategy proposed is lunacy and only designed to appease working mums. I would have thought the most pressing need is for Y11, Y12 and Y13 students, where every week is crucial, if they are intending on higher education. They are more disciplined and are in smaller classes. I am sure those who only go to school to eat their lunch, at this level, will take the opportunity to wag. Laboratory classes are hard to do over the internet and STEM subjects will suffer. These may be the very people we will rely on in the near future.
      There is no logic, just appeasement to a voting block.

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