Home NZ Politics The Reason Cindy Has Deteriorated In 2 Long Years

The Reason Cindy Has Deteriorated In 2 Long Years

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Beauty Sleep Could Be Real, Say Body Clock Biologists

University of Manchester

Biologists explain for first time why having a good night’s sleep really could prepare us for a busy day

Biologists from The University of Manchester have explained for the first time why having a good night’s sleep really could prepare us for the rigors of the day ahead.

The study in mice and published in Nature Cell Biology, shows how the body clock mechanism boosts our ability to maintain our bodies when we are most active.

And because we know the body clock is less precise as we age, the discovery, argues lead author Professor Karl Kadler, may one day help unlock some of the mysteries of aging.

The discovery throws fascinating light on the body’s extracellular matrix -which provides structural and biochemical support to cells in the form of connective tissue such as bone, skin, tendon and cartilage.

Over half our body weight is matrix, and half of this is collagen — and scientists have long understood it is fully formed by the time we reach the age of 17.

But now the researchers have discovered there are two types of fibrils — the rope-like structures of collagen that are woven by the cells to form tissues.

Thicker fibrils measuring about 200 nanometres in diameter — a million million times smaller than a pinhead — are permanent and stay with us throughout our lives, unchanged from the age of 17.

But thinner fibrils measuring 50 nanometres, they find, are sacrificial, breaking as we subject the body to the rigors of the day but replenishing when we rest at night.

The collagen was observed by mass spectrometry and the mouse fibrils were observed using state of the art volumetric electron microscopy — funded by the Wellcome Trust — every 4 hours over 2 days.

When the body clock genes where knocked out in mice, the thin and thick fibrils were amalgamated randomly.

“Collagen provides the body with structure and is our most abundant protein, ensuring the integrity, elasticity and strength of the body’s connective tissue,” said Professor Kadler

“It’s intuitive to think our matrix should be worn down by wear and tear, but it isn’t and now we know why: our body clock makes an element which is sacrificial and can be replenished, protecting the permanent parts of the matrix.

He added: “So if you imagine the bricks in the walls of a room as the permanent part, the paint on the walls could be seen as the sacrificial part which needs to be replenished every so often.

“And just like you need to oil a car and keep its radiator topped up with water, these thin fibrils help maintain the body’s matrix.”

“Knowing this could have implications on understanding our biology at its most fundamental level. It might, for example, give us some deeper insight into how wounds heal, or how we age.

It’s all very well for scientists to say the above, but they have given no weight to the affect lawnmower use will have. I guess being old age adjacent, Cindy’s body is trying to tell her something.

12 COMMENTS

  1. Mmmmmm interesting. I read Maggie Thatcher survived on 4 hours sleep a night and she looked age appropriate at the time of being PM of the UK, so maybe that’s not it for PTPM?

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  2. Seriously Ardern has very many different looks
    And she does many different things with her mouth, sometimes it twists up nearly to her ear.

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  3. The media won’t let you see how she really looks.

    She has a full production team doing flattering makeup and lighting. Only the very best images are shown. Photo shoots are digitally enhanced before publication.

    The very opposite of what they do with her opposition, or Trump.

    It is etched on Arderns face what she really is – a bitter twisted tormented little narcissist filled with malice.

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    • I sometimes wonder why she cannot seem to speak except in mainly rehearsed platitudes and why she can not recall what she has said on previous occasions and contradicts herself and tells lies. Cannabis use can cause that type of dysfunction. Can’t recall Ardern ever denying that she does not use cannabis. However I am sure that as PM she would not use it.

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  4. As I read that I was thinking “this is an infomercial and in a minute they will try and sell us colagen supplements.” Perhaps that’s what Cindy needs?

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    • They’ve got **no** show. Most people probably think 1080 is the name of a rock group or something…….

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